MD-PhD Student, Won Jun Kim, Receives NIH F30 Award

Won Jun Kim, fifth year student in the Tri-Institutional MD-PhD program, has received an F30 award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH)

This award will support Mr. Kim's research in the Omar Abdel-Wahab lab at the Sloan Kettering Institute, where he is currently a PhD student. In particular, the F30 was given for Mr. Kim's project Identifying mis-splicing-derived antigens in spliceosomal mutant myelodysplasia and targeting via T-cell receptor therapeutics, which he described by saying:

"RNA splicing factor gene mutations are prevalent in blood disorders and induce widespread, recurrent alternative splicing events. We propose a novel approach of targeting these mutations via antigen-based immunotherapies, based on the hypothesis that mis-spliced mRNAs give rise to meaningful tumor antigens. The proposed research will (1) contribute to the understanding of mis-spliced mRNAs as immunotherapeutic targets and (2) inspire T-cell receptor therapies for myelodysplastic syndromes and immunoprevention strategies for clonal hematopoiesis with spliceosomal mutations."

Won Jun Kim