| Title | Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Wong MM, Byun JS, Sacta M, Jin Q, Baek SJ, Gardner K |
| Journal | PLoS One |
| Volume | 9 |
| Issue | 6 |
| Pagination | e99989 |
| Date Published | 2014 |
| ISSN | 1932-6203 |
| Keywords | Cell Cycle Proteins, Cell Proliferation, Chromatin, Chromatin Assembly and Disassembly, Chromosomal Proteins, Non-Histone, E1A-Associated p300 Protein, Epigenesis, Genetic, Gene Knockout Techniques, HCT116 Cells, Histones, Humans, Inheritance Patterns, Jurkat Cells, Mediator Complex, Mitosis, Nuclear Proteins, Promoter Regions, Genetic, Protein Binding, RNA Polymerase II, Signal Transduction, TATA-Box Binding Protein, Transcription Factors, Transcription, Genetic |
| Abstract | A central hallmark of epigenetic inheritance is the parental transmission of changes in patterns of gene expression to progeny without modification of DNA sequence. Although, the trans-generational conveyance of this molecular memory has been traditionally linked to covalent modification of histone and/or DNA, recent studies suggest a role for proteins that persist or remain bound within chromatin to "bookmark" specific loci for enhanced or potentiated responses in daughter cells immediately following cell division. In this report we describe a role for p300 in enabling gene bookmarking by pre-initiation complexes (PICs) containing RNA polymerase II (pol II), Mediator and TBP. Once formed these complexes require p300 to enable reacquisition of protein complex assemblies, chromatin modifications and long range chromatin interactions that facilitate post-mitotic transmission of transcriptional memory of prior environmental stimuli. |
| DOI | 10.1371/journal.pone.0099989 |
| Alternate Journal | PLoS ONE |
| PubMed ID | 24945803 |
| PubMed Central ID | PMC4063784 |
| Grant List | / / Intramural NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:09pm