Submitted by api_import on June 6, 2018 - 4:10pm
| Title | Wnt Signaling and Colorectal Cancer. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Schatoff EM, Leach BI, Dow LE |
| Journal | Curr Colorectal Cancer Rep |
| Volume | 13 |
| Issue | 2 |
| Pagination | 101-110 |
| Date Published | 2017 Apr |
| ISSN | 1556-3790 |
| Abstract | The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically. |
| DOI | 10.1007/s11888-017-0354-9 |
| Alternate Journal | Curr Colorectal Cancer Rep |
| PubMed ID | 28413363 |
| PubMed Central ID | PMC5391049 |
| Grant List | K22 CA181280 / CA / NCI NIH HHS / United States R01 CA195787 / CA / NCI NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States |