Title | Where Hematopoietic Stem Cells Live: The Bone Marrow Niche. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Szade K, Gulati GS, Chan CKF, Kao KS, Miyanishi M, Marjon KD, Sinha R, George BM, Chen JY, Weissman IL |
Journal | Antioxid Redox Signal |
Volume | 29 |
Issue | 2 |
Pagination | 191-204 |
Date Published | 2018 07 10 |
ISSN | 1557-7716 |
Keywords | Animals, Bone Marrow Cells, Hematopoietic Stem Cells, Humans, Leukemia, Mesenchymal Stem Cells, Mice, Reactive Oxygen Species, Stem Cell Niche |
Abstract | SIGNIFICANCE: Hematopoietic stem cells (HSCs) can sustain the production of blood throughout one's lifetime. However, for proper self-renewal of its own population and differentiation to blood, the HSC requires a specialized microenvironment called the "niche." Recent Advances: Recent studies using novel mouse models have shed new light on the cellular architecture and function of the HSC niche. Here, we review the different cells that constitute the HSC niche and the molecular mechanisms that underlie HSC and niche interaction. We discuss the evidence and potential features that distinguish the HSC niche from other microenvironments in the bone marrow. The relevance of the niche in malignant transformation of the HSCs and harboring cancer metastasis to the bone is also outlined. In addition, we address how the niche may regulate reactive oxygen species levels surrounding the HSCs. Critical Issues and Future Directions: We propose future directions and remaining challenges in investigating the niche of HSCs. We discuss how a better understanding of the HSC niche may help in restoring an aged hematopoietic system, fighting against malignancies, and transplanting purified HSCs safely and effectively into patients. Antioxid. Redox Signal. 00, 000-000. |
DOI | 10.1089/ars.2017.7419 |
Alternate Journal | Antioxid. Redox Signal. |
PubMed ID | 29113449 |
PubMed Central ID | PMC6016729 |
Grant List | T32 CA009302 / CA / NCI NIH HHS / United States T32 DK098132 / DK / NIDDK NIH HHS / United States |
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