Title | Stem cell-driven lymphatic remodeling coordinates tissue regeneration. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse J, Kataru RP, Liu X, de la Cruz-Racelis J, Mehrara BJ, Fuchs E |
Journal | Science |
Volume | 366 |
Issue | 6470 |
Pagination | 1218-1225 |
Date Published | 2019 12 06 |
ISSN | 1095-9203 |
Abstract | Tissues rely on stem cells (SCs) for homeostasis and wound repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC-niche components. In skin, lymphatics form intimate networks around hair follicle (HF) SCs. When HFs regenerate, lymphatic-SC connections become dynamic. Using a mouse model, we unravel a secretome switch in SCs that controls lymphatic behavior. Resting SCs express angiopoietin-like protein 7 (), promoting lymphatic drainage. Activated SCs switch to , triggering transient lymphatic dissociation and reduced drainage. When lymphatics are perturbed or the secretome switch is disrupted, HFs cycle precociously and tissue regeneration becomes asynchronous. In unearthing lymphatic capillaries as a critical SC-niche element, we have learned how SCs coordinate their activity across a tissue. |
DOI | 10.1126/science.aay4509 |
Alternate Journal | Science |
PubMed ID | 31672914 |
Grant List | F31 CA236465 / CA / NCI NIH HHS / United States R01 AR050452 / AR / NIAMS NIH HHS / United States R01 AR031737 / AR / NIAMS NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States |
Submitted by api_import on November 27, 2019 - 9:49am