Title | Pluripotent stem cells in neuropsychiatric disorders. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Soliman MA, Aboharb F, Zeltner N, Studer L |
Journal | Mol Psychiatry |
Volume | 22 |
Issue | 9 |
Pagination | 1241-1249 |
Date Published | 2017 09 |
ISSN | 1476-5578 |
Keywords | Bipolar Disorder, Humans, Induced Pluripotent Stem Cells, Mental Disorders, Pluripotent Stem Cells, Precision Medicine, Schizophrenia |
Abstract | Neuropsychiatric disorders place an enormous medical burden on patients across all social and economic ranks. The current understanding of the molecular and cellular causes of neuropsychiatric disease remains limited, which leads to a lack of targeted therapies. Human-induced pluripotent stem cell (iPSC) technology offers a novel platform for modeling the genetic contribution to mental disorders and yields access to patient-specific cells for drug discovery and personalized medicine. Here, we review recent progress in using iPSC technology to model and potentially treat neuropsychiatric disorders by focusing on the most prevalent conditions in psychiatry, including depression, anxiety disorders, bipolar disorder and schizophrenia. |
DOI | 10.1038/mp.2017.40 |
Alternate Journal | Mol. Psychiatry |
PubMed ID | 28322279 |
PubMed Central ID | PMC5582162 |
Grant List | P30 CA008748 / CA / NCI NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States R01 NS072381 / NS / NINDS NIH HHS / United States R21 NS084334 / NS / NINDS NIH HHS / United States |
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