Title | Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Azim E, Shnider SJ, Cederquist GY, U Sohur S, Macklis JD |
Journal | Cereb Cortex |
Volume | 19 Suppl 1 |
Pagination | i62-9 |
Date Published | 2009 Jul |
ISSN | 1460-2199 |
Keywords | Adaptor Proteins, Signal Transducing, Animals, Homeodomain Proteins, LIM Domain Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neocortex, Nerve Net, Neurons, Transcription Factors |
Abstract | Molecular controls over the development of the exceptional neuronal subtype diversity of the cerebral cortex are now beginning to be identified. The initial subtype fate decision early in the life of a neuron, and the malleability of this fate when the balance of key postmitotic signals is modified, reveals not only that a neuron is deterministically set on a general developmental path at its birth, but also that this program must be precisely executed during postmitotic differentiation. Here, we show that callosal projection neurons (CPN) and subcerebral projection neurons (subcerebral PN) in layer V of the neocortex share aspects of molecular identity after their birth that are progressively resolved during differentiation. The LIM-homeodomain-related genes Lmo4 and Clim1 are initially expressed by both CPN and subcerebral PN in layer V, and only during mid to late differentiation does expression of Lmo4 and Clim1 become largely segregated into distinct neuronal subtypes. This progressive postmitotic resolution of molecular identity reveals similarities and possibly shared evolutionary origin between layer V CPN and subcerebral PN, and provides insight into how and when these neuronal subtypes achieve their distinct identities during cortical development. |
DOI | 10.1093/cercor/bhp030 |
Alternate Journal | Cereb. Cortex |
PubMed ID | 19366868 |
PubMed Central ID | PMC2693532 |
Grant List | F31 NS060421 / NS / NINDS NIH HHS / United States NS49553 / NS / NINDS NIH HHS / United States NS45523 / NS / NINDS NIH HHS / United States F31 NS063516 / NS / NINDS NIH HHS / United States NS41590 / NS / NINDS NIH HHS / United States |
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