Title | Impact of human immunodeficiency virus on neurocognition and risky behaviors in young adults. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Baker LM, Paul RH, Heaps JM, Westerhaus E, Chang JYoon, Williams S, Brier MR, Plax K, Ances BM |
Journal | J Neurovirol |
Volume | 20 |
Issue | 5 |
Pagination | 466-73 |
Date Published | 2014 Oct |
ISSN | 1538-2443 |
Keywords | Adolescent, Cognition Disorders, Female, HIV Infections, Humans, Male, Neuropsychological Tests, Risk-Taking, Young Adult |
Abstract | Previous studies have identified cognitive impairments due to human immunodeficiency virus (HIV) in adults. However, few studies have examined the impact of HIV on cognition in young adults (18-24 years old). Yet, this group is one of the largest populations of individuals with new HIV infection. Young adulthood is also an important developmental window because the brain has not fully matured and individuals are prone to engage in risky behavior. The purpose of the present study was to examine the impact of HIV on neurocognition and risky behaviors. We hypothesized that HIV+ young adults (n = 23) would exhibit greater cognitive impairment and risky behaviors compared to seronegative controls (n = 21). In addition, we predicted that self-reported risky behavior as assessed by the Risk Assessment Battery (RAB) would covary with cognitive performances. Results revealed poorer executive function in HIV+ young adults compared to seronegative (HIV-) controls. HIV+ young adults exhibited significantly greater risk scores on the RAB (p < 0.01) compared to HIV- young adults. However, there were no relationships between risky behavior and cognitive performance. Overall, our results suggest that HIV is associated with poorer cognition and increased risky behaviors in young adults. |
DOI | 10.1007/s13365-014-0264-4 |
Alternate Journal | J. Neurovirol. |
PubMed ID | 24970235 |
PubMed Central ID | PMC4305333 |
Grant List | R21 MH099979 / MH / NIMH NIH HHS / United States R01 NS052420 / NS / NINDS NIH HHS / United States R25 MH080663 / MH / NIMH NIH HHS / United States R01MH085604 / MH / NIMH NIH HHS / United States R01 NR012907 / NR / NINR NIH HHS / United States K23 MH081786 / MH / NIMH NIH HHS / United States R01 NR014449 / NR / NINR NIH HHS / United States R01 NR012657 / NR / NINR NIH HHS / United States UL1 TR000448 / TR / NCATS NIH HHS / United States R01 MH085604 / MH / NIMH NIH HHS / United States R21MH099979 / MH / NIMH NIH HHS / United States |
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