Submitted by api_import on December 20, 2019 - 3:17pm
| Title | Ets transcription factor GABP controls T cell homeostasis and immunity. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Luo CT, Osmanbeyoglu HU, Do MH, Bivona MR, Toure A, Kang D, Xie Y, Leslie CS, Li MO |
| Journal | Nat Commun |
| Volume | 8 |
| Issue | 1 |
| Pagination | 1062 |
| Date Published | 2017 10 20 |
| ISSN | 2041-1723 |
| Keywords | Adaptive Immunity, Animals, Antigens, Binding Sites, CD4 Antigens, Cell Proliferation, Cells, Cultured, DNA Replication, GA-Binding Protein Transcription Factor, Homeostasis, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Knockout, Minichromosome Maintenance Proteins, T-Lymphocytes, Transcription, Genetic |
| Abstract | Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity. |
| DOI | 10.1038/s41467-017-01020-6 |
| Alternate Journal | Nat Commun |
| PubMed ID | 29051483 |
| PubMed Central ID | PMC5648787 |
| Grant List | K99 CA207871 / CA / NCI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States |