Title | An essential role for the IL-2 receptor in T cell function. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY |
Journal | Nat Immunol |
Volume | 17 |
Issue | 11 |
Pagination | 1322-1333 |
Date Published | 2016 Nov |
ISSN | 1529-2916 |
Keywords | Animals, Biomarkers, CD8-Positive T-Lymphocytes, Cytokines, Female, Immunomodulation, Male, Mice, Mice, Knockout, Mice, Transgenic, Phenotype, Receptors, Interleukin-2, STAT5 Transcription Factor, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory |
Abstract | Regulatory T cells (T cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by T cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the T cell lineage-specification factor Foxp3, which has confounded experimental efforts to understand the role of IL-2R expression and signaling in the suppressor function of T cells. Using genetic gain- and loss-of-function approaches, we found that capture of IL-2 was dispensable for the control of CD4 T cells but was important for limiting the activation of CD8 T cells, and that IL-2R-dependent activation of the transcription factor STAT5 had an essential role in the suppressor function of T cells separable from signaling via the T cell antigen receptor. |
DOI | 10.1038/ni.3540 |
Alternate Journal | Nat. Immunol. |
PubMed ID | 27595233 |
PubMed Central ID | PMC5071159 |
Grant List | P30 CA008748 / CA / NCI NIH HHS / United States R37 AI034206 / AI / NIAID NIH HHS / United States / / Howard Hughes Medical Institute / United States F30 AI122721 / AI / NIAID NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States R01 AI107027 / AI / NIAID NIH HHS / United States P30 CA014195 / CA / NCI NIH HHS / United States |
Submitted by api_import on June 6, 2018 - 4:10pm