Submitted by kej2006 on June 6, 2018 - 4:10pm
Title | A structural view of the COPII vesicle coat. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Bickford LC, Mossessova E, Goldberg J |
Journal | Curr Opin Struct Biol |
Volume | 14 |
Issue | 2 |
Pagination | 147-53 |
Date Published | 2004 Apr |
ISSN | 0959-440X |
Keywords | Carrier Proteins, COP-Coated Vesicles, Golgi Apparatus, GTPase-Activating Proteins, Guanosine Triphosphate, Membrane Proteins, Models, Molecular, Monomeric GTP-Binding Proteins, Nuclear Pore Complex Proteins, Phosphoproteins, Protein Transport, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Vesicular Transport Proteins |
Abstract | The COPII vesicle coat coordinates the budding of transport vesicles from the endoplasmic reticulum in the initial step of the secretory pathway. The coat orchestrates a sequence of events including self-assembly on the membrane, cargo and SNARE molecule selection, and deformation of the membrane into a bud to drive vesicle fission. Recent molecular-level studies have helped to explain how the three components of yeast COPII - Sar1 GTPase, the Sec23/24 subcomplex and the Sec13/31 subcomplex - combine to organize this complex process. |
DOI | 10.1016/j.sbi.2004.02.002 |
Alternate Journal | Curr. Opin. Struct. Biol. |
PubMed ID | 15093828 |