Title | A square signal wave method for measurement of brain extra- and intracellular water content. |
Publication Type | Journal Article |
Year of Publication | 1994 |
Authors | Itkis ML, Roberts JK, Ghajar JB, Hariri RJ |
Journal | Acta Neurochir Suppl (Wien) |
Volume | 60 |
Pagination | 574-6 |
Date Published | 1994 |
Keywords | Animals, Brain Edema, Calibration, Cerebral Cortex, Electric Impedance, Extracellular Space, Intracellular Fluid, Rats, Signal Processing, Computer-Assisted, Software |
Abstract | Brain tissue electrical impedance is a commonly used method to evaluate the dynamics of brain edema. We have found the square wave impedance method simpler and more cost-effective than the currently used sine wave impedance method. This square wave method avoids the necessity for expensive frequency control and amplitude-phase measuring devices as well as simplifying on-line data processing. In our experiments the electrical impulse was generated by a pulse generator of Macintosh data acquisition system. The signal (I = 11 muA, t = 2-20 ms) was delivered every 2-3 s external electrodes of a tetrapolar system through a specially designed isolation-calibration device. This electrode system was inserted into the cerebral cortex of experimental animals (rat). The cerebral cortex was found to have linear electrical properties in the 5-30 muA range. Our impedance measurement system was tested in calibration trials, and showed system reliability and accuracy. The system was also tested in pilot experiments, in vivo, in a rat brain osmotic edema model. |
Alternate Journal | Acta Neurochir Suppl (Wien) |
PubMed ID | 7976654 |
Submitted by kej2006 on June 6, 2018 - 4:10pm