Title | Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV |
Journal | Virulence |
Volume | 9 |
Issue | 1 |
Pagination | 804-817 |
Date Published | 2018 12 31 |
ISSN | 2150-5608 |
Abstract | Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions. |
DOI | 10.1080/21505594.2018.1449508 |
Alternate Journal | Virulence |
PubMed ID | 29532717 |
PubMed Central ID | PMC5955448 |
Grant List | P30 AG013319 / AG / NIA NIH HHS / United States R01 AG044768 / AG / NIA NIH HHS / United States K22 AI110552 / AI / NIAID NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:13pm