Submitted by kej2006 on June 6, 2018 - 4:13pm
| Title | Palladium(II)-Catalyzed Mono- and Bis-alkenylation of N-Acetyl-2-aminobiaryls through Regioselective C-H Bond Activation. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Annamalai P, Hsu K-C, Raju S, Hsiao H-C, Chou C-W, Lin G-Y, Hsieh C-M, Chen P-L, Liu Y-H, Chuang S-C |
| Journal | J Org Chem |
| Volume | 83 |
| Issue | 7 |
| Pagination | 3840-3856 |
| Date Published | 2018 04 06 |
| ISSN | 1520-6904 |
| Abstract | We developed palladium-catalyzed oxidative coupling of olefins with N-acyl 2-aminobiaryls through a sequence of ortho C-H bond activation/alkene insertion/reductive elimination. Furthermore, we controlled the selectivity of mono- and bis-alkenylation products with the solvent effect. The developed protocol was promising for a broad substrate scope ranging from activated olefins with a wide variety of functional groups to unactivated olefins. |
| DOI | 10.1021/acs.joc.8b00194 |
| Alternate Journal | J. Org. Chem. |
| PubMed ID | 29521504 |