Title | Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Gaeta SA, Christini DJ |
Journal | Front Physiol |
Volume | 3 |
Pagination | 157 |
Date Published | 2012 |
ISSN | 1664-042X |
Abstract | Cardiac repolarization alternans is a rhythm disturbance of the heart in which rapid stimulation elicits a beat-to-beat alternation in the duration of action potentials and magnitude of intracellular calcium transients in individual cardiac myocytes. Although this phenomenon has been identified as a potential precursor to dangerous reentrant arrhythmias and sudden cardiac death, significant uncertainty remains regarding its mechanism and no clinically practical means of halting its occurrence or progression currently exists. Cardiac alternans has well-characterized tissue, cellular, and subcellular manifestations, the mechanisms and interplay of which are an active area of research. |
DOI | 10.3389/fphys.2012.00157 |
Alternate Journal | Front Physiol |
PubMed ID | 22783195 |
PubMed Central ID | PMC3389489 |
Grant List | T32 GM007739 / GM / NIGMS NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:11pm