Submitted by kej2006 on June 6, 2018 - 4:10pm
Title | Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Amprey JL, Späth GF, Porcelli SA |
Journal | Infect Immun |
Volume | 72 |
Issue | 1 |
Pagination | 589-92 |
Date Published | 2004 Jan |
ISSN | 0019-9567 |
Keywords | Animals, Antigens, CD1, Cell Line, Cells, Cultured, Dendritic Cells, Down-Regulation, Humans, Leishmania donovani, Leishmaniasis, Visceral, Lymphocyte Activation, T-Lymphocytes |
Abstract | Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids. |
Alternate Journal | Infect. Immun. |
PubMed ID | 14688141 |
PubMed Central ID | PMC343976 |
Grant List | GM07739 / GM / NIGMS NIH HHS / United States R01 AI045889 / AI / NIAID NIH HHS / United States AI48933 / AI / NIAID NIH HHS / United States AI45889 / AI / NIAID NIH HHS / United States R01 AI048933 / AI / NIAID NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States |