Found 35 results
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2021
Duarte RRR, Copertino DC, Iñiguez LP, Marston JL, Bram Y, Han Y, Schwartz RE, Chen S, Nixon DF, Powell TR.  2021.  Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry.. Mol Med. 27(1):105.
2020
Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F et al..  2020.  A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.. Cell Stem Cell. 27(1):125-136.e7.
2019
Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh C-L, Yang D et al..  2019.  Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation.. Nat Genet. 51(6):999-1010.
2018
Delgado-Benito V, Rosen DB, Wang Q, Gazumyan A, Pai JA, Oliveira TY, Sundaravinayagam D, Zhang W, Andreani M, Keller L et al..  2018.  The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination.. Mol Cell. 72(4):636-649.e8.
Teijeiro V, Yang D, Majumdar S, González F, Rickert RW, Xu C, Koche R, Verma N, Lai EC, Huangfu D.  2018.  DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells.. Stem Cell Reports. 11(3):616-625.
Reed JC, Westergreen N, Barajas BC, Ressler DTB, Phuong DJ, Swain JV, Lingappa VR, Lingappa JR.  2018.  Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus.. J Virol. 92(9)
Zhang P, Zhao G, Ji L, Yin J, Lu L, Li W, Zhou G, Chaum E, Yue J.  2018.  Knockdown of survivin results in inhibition of epithelial to mesenchymal transition in retinal pigment epithelial cells by attenuating the TGFβ pathway.. Biochem Biophys Res Commun. 498(3):573-578.
Zafra MPaz, Schatoff EM, Katti A, Foronda M, Breinig M, Schweitzer AY, Simon A, Han T, Goswami S, Montgomery E et al..  2018.  Optimized base editors enable efficient editing in cells, organoids and mice.. Nat Biotechnol. 36(9):888-893.
Goyal N, Rossi MJ, Mazina OM, Chi Y, Moritz RL, Clurman BE, Mazin AV.  2018.  RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions.. Nat Commun. 9(1):34.
2017
Shi Z-D, Lee K, Yang D, Amin S, Verma N, Li QV, Zhu Z, Soh C-L, Kumar R, Evans T et al..  2017.  Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.. Cell Stem Cell. 20(5):675-688.e6.
Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, Tomishima M, Brennand KJ, Zhang Q, Schwartz RE et al..  2017.  High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.. Cell Stem Cell. 21(2):274-283.e5.
Wickersham M, Wachtel S, Lung TWong Fok, Soong G, Jacquet R, Richardson A, Parker D, Prince A.  2017.  Metabolic Stress Drives Keratinocyte Defenses against Staphylococcus aureus Infection.. Cell Rep. 18(11):2742-2751.
Kawamata H, Peixoto P, Konrad C, Palomo G, Bredvik K, Gerges M, Valsecchi F, Petrucelli L, Ravits JM, Starkov A et al..  2017.  Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo.. Mol Neurodegener. 12(1):37.
Fu C, Xu J, Cheng W, Rojas T, Chin AC, Snowman AM, Harraz MM, Snyder SH.  2017.  Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.. Proc Natl Acad Sci U S A. 114(8):2036-2041.
Monahan Z, Ryan VH, Janke AM, Burke KA, Rhoads SN, Zerze GH, O'Meally R, Dignon GL, Conicella AE, Zheng W et al..  2017.  Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.. EMBO J. 36(20):2951-2967.
Lv Z, Rickman KA, Yuan L, Williams K, Selvam SPanneer, Woosley AN, Howe PH, Ogretmen B, Smogorzewska A, Olsen SK.  2017.  S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.. Mol Cell. 65(4):699-714.e6.
Du W, Seah I, Bougazzoul O, Choi GH, Meeth K, Bosenberg MW, Wakimoto H, Fisher D, Shah K.  2017.  Stem cell-released oncolytic herpes simplex virus has therapeutic efficacy in brain metastatic melanomas.. Proc Natl Acad Sci U S A. 114(30):E6157-E6165.
Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, van Haaften G, van Haelst MM, van Empelen R, Cuppen I et al..  2017.  Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.. J Clin Invest. 127(3):1005-1018.
2016
Hoban MD, Lumaquin D, Kuo CY, Romero Z, Long J, Ho M, Young CS, Mojadidi M, Fitz-Gibbon S, Cooper AR et al..  2016.  CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells.. Mol Ther. 24(9):1561-9.
Feelixge HSDe Silva, Stone D, Pietz HL, Roychoudhury P, Greninger AL, Schiffer JT, Aubert M, Jerome KR.  2016.  Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy.. Antiviral Res. 126:90-8.
Lu C-L, Murakowski DK, Bournazos S, Schoofs T, Sarkar D, Halper-Stromberg A, Horwitz JA, Nogueira L, Golijanin J, Gazumyan A et al..  2016.  Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.. Science. 352(6288):1001-4.
Henssen AG, Jiang E, Zhuang J, Pinello L, Socci ND, Koche R, Gönen M, Villasante CM, Armstrong SA, Bauer DE et al..  2016.  Forward genetic screen of human transposase genomic rearrangements.. BMC Genomics. 17:548.
Simsek S, Zhou T, Robinson CL, Tsai S-Y, Crespo M, Amin S, Lin X, Hon J, Evans T, Chen S.  2016.  Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells.. Stem Cells Transl Med. 5(5):572-9.
Kitur K, Wachtel S, Brown A, Wickersham M, Paulino F, Peñaloza HF, Soong G, Bueno S, Parker D, Prince A.  2016.  Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling.. Cell Rep. 16(8):2219-2230.
Halberg N, Sengelaub CA, Navrazhina K, Molina H, Uryu K, Tavazoie SF.  2016.  PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion.. Cancer Cell. 29(3):339-353.