| Title | Impact of Melatonin on Sleep and Pain After Total Knee Arthroplasty Under Regional Anesthesia With Sedation: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Kirksey MA, Yoo D, Danninger T, Stundner O, Ma Y, Memtsoudis SG |
| Journal | J Arthroplasty |
| Volume | 30 |
| Issue | 12 |
| Pagination | 2370-5 |
| Date Published | 2015 Dec |
| ISSN | 1532-8406 |
| Keywords | Aged, Anesthesia, Conduction, Arthroplasty, Replacement, Knee, Central Nervous System Depressants, Double-Blind Method, Female, Humans, Male, Melatonin, Middle Aged, Pain, Postoperative, Pilot Projects, Sleep, Sleep Wake Disorders |
| Abstract | This pilot study explores sleep disruption after total knee arthroplasty and the impact of melatonin on sleep and postoperative pain. Sleep time was decreased on the last preoperative night and first two postoperative nights. Sleep efficiency was decreased on all three postoperative nights. Compared to placebo, melatonin increased sleep efficiency by 4.4% (mean; 95% CI -1.6, 10.4; P=0.150) and sleep time by 29 min (mean; 95% CI -2.0, 60.4; P=0.067). Melatonin appeared to have no effect on subjective sleep quality or daytime sleepiness, pain at rest or pain with standardized activity. In conclusion, sleep quality is impaired after total knee arthroplasty and exogenous melatonin does not appear to improve postoperative sleep or pain to a significant degree. |
| DOI | 10.1016/j.arth.2015.06.034 |
| Alternate Journal | J Arthroplasty |
| PubMed ID | 26173613 |
Submitted by kej2006 on June 6, 2018 - 4:11pm