Title | Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adults. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Chiu H-F, Chen B-K, Lu Y-Y, Han Y-C, Shen Y-C, Venkatakrishnan K, Golovinskaia O, Wang C-K |
Journal | Pharm Biol |
Volume | 55 |
Issue | 1 |
Pagination | 497-502 |
Date Published | 2017 Dec |
ISSN | 1744-5116 |
Keywords | Anticholesteremic Agents, Biomarkers, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Fatty Acids, Female, Gonadal Steroid Hormones, Humans, Hypercholesterolemia, Male, Risk Factors, Single-Blind Method, Taiwan, Time Factors, Treatment Outcome, Triglycerides |
Abstract | CONTEXT: Royal jelly (RJ) has been reported for its health promoting factors such as antioxidant, anti-inflammatory and lipid lowering activities. OBJECTIVE: The present randomized, placebo-controlled study examines the hypolipidemic beneficial effect of RJ through evaluating anthropometric measurements, lipid profile and various hormone levels in mildly hypercholesterolemic participants. MATERIALS AND METHODS: Forty subjects with mild hypercholesterolemia (180-200 mg/dL) were randomly selected and divided into two groups as experimental or placebo, who requested to intake nine capsules (350 mg/capsule) of RJ or placebo/day, respectively, for three months with one month of follow-up without any supplementation. RESULTS: No significant changes were noted in any of the anthropometric parameters like body weight, waist and body fat. The serum total cholesterol (TC; 207.05-183.15 mg/dL) and low-density lipoprotein cholesterol (LDL-c; 126.44-120.31 mg/dL) levels were reduced significantly (p < 0.05) after administration of RJ. However, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-c) levels were not considerably altered. Moreover, three months of RJ consumption significantly ameliorated (p < 0.05) the concentration of sex hormones like dehydroepiandrosterone sulphate (DHEA-S; 1788.09-1992.31 ng/mL). Also, intake of RJ did not elicit any hepatic or renal damage. DISCUSSION AND CONCLUSION: Intervention with RJ for three months considerably lowered the TC and LDL-c levels through improving the levels of DHEA-S and thus alleviates the risk of cardiovascular disease (CVD). |
DOI | 10.1080/13880209.2016.1253110 |
Alternate Journal | Pharm Biol |
PubMed ID | 27937077 |
Submitted by kej2006 on June 6, 2018 - 4:11pm