Title | A holey pursuit: lumen formation in the developing kidney. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Marciano DK |
Journal | Pediatr Nephrol |
Volume | 32 |
Issue | 1 |
Pagination | 7-20 |
Date Published | 2017 Jan |
ISSN | 1432-198X |
Keywords | Animals, Humans, Kidney, Kidney Tubules, Morphogenesis, Organogenesis |
Abstract | The formation of polarized epithelial tubules is a hallmark of kidney development. One of the fundamental principles in tubulogenesis is that epithelia coordinate the polarity of individual cells with the surrounding cells and matrix. A central feature in this process is the segregation of membranes into spatially and functionally distinct apical and basolateral domains, and the generation of a luminal space at the apical surface. This review examines our current understanding of the cellular and molecular mechanisms that underlie the establishment of apical-basal polarity and lumen formation in developing renal epithelia, including the roles of cell-cell and cell-matrix interactions and polarity complexes. We highlight growing evidence from animal models, and correlate these findings with models of tubulogenesis from other organ systems, and from in vitro studies. |
DOI | 10.1007/s00467-016-3326-4 |
Alternate Journal | Pediatr. Nephrol. |
PubMed ID | 26902755 |
PubMed Central ID | PMC5495142 |
Grant List | R01 DK099478 / DK / NIDDK NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:11pm