Title | Fcγ Receptor Function and the Design of Vaccination Strategies. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Bournazos S, Ravetch JV |
Journal | Immunity |
Volume | 47 |
Issue | 2 |
Pagination | 224-233 |
Date Published | 2017 08 15 |
ISSN | 1097-4180 |
Keywords | Animals, Humans, Immunoglobulin Fc Fragments, Immunoglobulin Isotypes, Immunomodulation, Receptors, IgG, Signal Transduction, T-Lymphocytes, Regulatory, Vaccination, Vaccines |
Abstract | Through specific interactions with distinct types of Fcγ receptors (FcγRs), the Fc domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence both innate and adaptive responses. Recent studies indicate that IgG Fc-FcγR interactions are dynamically regulated during an immune response through the control of the Fc-associated glycan structure and Ig subclass composition on the one hand and selective FcγR expression on immune cells on the other, which together determine the capacity of IgG to interact in a cell-type-specific manner with specific members of the FcγR family. Here, we present a framework that synthesizes the current understanding of the contribution of FcγR pathways to the induction and regulation of antibody and T cell responses. Within this context, we discuss vaccination strategies to elicit broad and potent immune responses based on the immunomodulatory properties of Fc-FcγR interactions. |
DOI | 10.1016/j.immuni.2017.07.009 |
Alternate Journal | Immunity |
PubMed ID | 28813656 |
PubMed Central ID | PMC5573140 |
Grant List | P01 AI100148 / AI / NIAID NIH HHS / United States U19 AI109946 / AI / NIAID NIH HHS / United States P01 CA190174 / CA / NCI NIH HHS / United States R35 CA196620 / CA / NCI NIH HHS / United States U19 AI111825 / AI / NIAID NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:12pm