Title | The effect of acellular dermal matrix use on complication rates in tissue expander/implant breast reconstruction. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Lanier ST, Wang ED, Chen JJ, Arora BP, Katz SM, Gelfand MA, Khan SU, Dagum AB, Bui DT |
Journal | Ann Plast Surg |
Volume | 64 |
Issue | 5 |
Pagination | 674-8 |
Date Published | 2010 May |
ISSN | 1536-3708 |
Keywords | Biocompatible Materials, Breast Implantation, Breast Implants, Breast Neoplasms, Collagen, Female, Humans, Mammaplasty, Middle Aged, Necrosis, Postoperative Complications, Retrospective Studies, Tissue Expansion Devices, Treatment Outcome |
Abstract | Tissue expander/implant breast reconstructions by 5 surgeons at a single institution from 2005 to 2008 were retrospectively identified and divided into 2 cohorts: use of acellular dermal matrix (ADM, n = 75) versus standard submuscular placement (n = 52). The ADM group had a statistically significant higher rate of infection (28.9% vs. 12.0%, P = 0.022), reoperation (25.0% vs. 8.0%, P = 0.011), expander explantation (19.2% vs. 5.3%, P = 0.020), and overall complications (46.2% vs. 22.7%, P = 0.007). When stratifying by breast size, a higher complication rate was not observed with the use of ADM in breasts less than 600 g, whereas ADM use in breasts larger than 600 g was associated with a statistically significant higher rate of infection when controlling for the occurrence of skin necrosis. The ADM cohort had a significantly higher mean initial tissue expander fill volume (256 mL vs. 74 mL, P < 0.001) and a significantly higher mean initial tissue expander fill ratio (49% vs. 17%, P < 0.001). Further work is needed to define the ideal patient population for ADM use in tissue expander/implant breast reconstruction. |
DOI | 10.1097/SAP.0b013e3181dba892 |
Alternate Journal | Ann Plast Surg |
PubMed ID | 20395795 |
Submitted by kej2006 on June 6, 2018 - 4:10pm