Title | Ribosomal profiling of human endogenous retroviruses in healthy tissues. |
Publication Type | Journal Article |
Year of Publication | 2024 |
Authors | Dopkins N, Singh B, Michael S, Zhang P, Marston JL, Fei T, Singh M, Feschotte C, Collins N, Bendall ML, Nixon DF |
Journal | BMC Genomics |
Volume | 25 |
Issue | 1 |
Pagination | 5 |
Date Published | 2024 Jan 02 |
ISSN | 1471-2164 |
Keywords | Endogenous Retroviruses, Humans, Ribosomes |
Abstract | Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding functions, while their protein coding capacity remains virtually uncharacterized. Therefore, we applied the bioinformatic pipeline "hervQuant" to high-resolution ribosomal profiling of healthy tissues to provide a comprehensive overview of translationally active HERVs. We find that HERVs account for 0.1-0.4% of all translation in distinct tissue-specific profiles. Collectively, our study further supports claims that HERVs are actively translated throughout healthy tissues to provide sequences of retroviral origin to the human proteome. |
DOI | 10.1186/s12864-023-09909-x |
Alternate Journal | BMC Genomics |
PubMed ID | 38166631 |
PubMed Central ID | PMC10759522 |
Grant List | R35 GM122550 / GM / NIGMS NIH HHS / United States |
Submitted by bel2021 on February 16, 2024 - 10:46am