Reframing antimicrobial resistance as a continuous spectrum of manifestations.

TitleReframing antimicrobial resistance as a continuous spectrum of manifestations.
Publication TypeJournal Article
Year of Publication2023
AuthorsSchrader SM, Botella H, Vaubourgeix J
JournalCurr Opin Microbiol
Date Published2023 Jan 04

To fight antimicrobial resistance (AMR), we must recognize and target all its manifestations. In this review, we briefly summarize the history that led to recognition of the various manifestations of AMR in bacterial pathogens and the ways in which they interrelate. We emphasize the importance of distinguishing between AMR arising from genetic alterations versus induction of endogenous machinery in response to environmental triggers, including - paradoxically - stresses from host immunity and antimicrobial therapy. We present an integrated view of AMR by reframing it as a spectrum of phenotypes within a continuous three-dimensional space defined by the growth rate, prevalence, and kill rate of cells displaying AMR. Finally, we reflect on strategies that may help stem the emergence of AMR.

Alternate JournalCurr Opin Microbiol
PubMed ID36608373

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