Title | Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Weizman O-E, Song E, Adams NM, Hildreth AD, Riggan L, Krishna C, Aguilar OA, Leslie CS, Carlyle JR, Sun JC, O'Sullivan TE |
Journal | Nat Immunol |
Volume | 20 |
Issue | 8 |
Pagination | 1004-1011 |
Date Published | 2019 08 |
ISSN | 1529-2916 |
Keywords | Animals, Herpesviridae Infections, Immunity, Innate, Immunologic Memory, Interleukin-18 Receptor alpha Subunit, Liver, Lymphocytes, Membrane Glycoproteins, Mice, Muromegalovirus, Viral Envelope Proteins |
Abstract | Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner. |
DOI | 10.1038/s41590-019-0430-1 |
Alternate Journal | Nat. Immunol. |
PubMed ID | 31263280 |
PubMed Central ID | PMC6697419 |
Grant List | F30 AI136239 / AI / NIAID NIH HHS / United States R01 AI145997 / AI / NIAID NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States |
Submitted by bel2021 on December 2, 2019 - 10:08am