Title | Metabolic regulation of the hallmarks of stem cell biology. |
Publication Type | Journal Article |
Year of Publication | 2024 |
Authors | Jackson BT, Finley LWS |
Journal | Cell Stem Cell |
Volume | 31 |
Issue | 2 |
Pagination | 161-180 |
Date Published | 2024 Feb 01 |
ISSN | 1875-9777 |
Keywords | Cell Differentiation, Cell Division, Stem Cells |
Abstract | Stem cells perform many different functions, each of which requires specific metabolic adaptations. Over the past decades, studies of pluripotent and tissue stem cells have uncovered a range of metabolic preferences and strategies that correlate with or exert control over specific cell states. This review aims to describe the common themes that emerge from the study of stem cell metabolism: (1) metabolic pathways supporting stem cell proliferation, (2) metabolic pathways maintaining stem cell quiescence, (3) metabolic control of cellular stress responses and cell death, (4) metabolic regulation of stem cell identity, and (5) metabolic requirements of the stem cell niche. |
DOI | 10.1016/j.stem.2024.01.003 |
Alternate Journal | Cell Stem Cell |
PubMed ID | 38306993 |
PubMed Central ID | PMC10842269 |
Grant List | F30 HD107943 / HD / NICHD NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States |
Submitted by bel2021 on April 26, 2024 - 2:40pm