Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa.

BACKGROUND: Hidradenitis Suppurativa (HS) is now recognized as a systemic inflammatory disease, sharing molecular similarities with psoriasis. Direct comparison of the systemic inflammation in HS with psoriasis is lacking.

OBJECTIVES: To evaluate the serum proteome of HS and psoriasis, and to identify biomarkers associated with disease severity.

METHODS: In this cross-sectional study, 1,536 serum proteins were assessed using the Olink Explore (Proximity Extension Assay/PEA) high-throughput panel in moderate-to-severe HS (n=11), psoriasis (n=10) and age- and BMI-matched healthy controls (n=10).

RESULTS: HS displayed an overall greater dysregulation of circulating proteins, with 434 differentially expressed proteins (|FCH|≥1.2, p-value≤0.05) in HS versus controls, 138 in psoriasis versus controls, and 503 between HS and psoriasis. IL-17A levels and Th1/Th17 pathway enrichment were comparable between diseases, while HS presented greater TNF and IL-1β-related signaling. Th17-associated markers, PI3 and LCN2, were able to accurately differentiate psoriasis from HS. Both diseases presented increases of atherosclerosis-related proteins. Robust correlations between clinical severity scores and immune and atherosclerosis-related proteins were observed across both diseases.

CONCLUSIONS: HS and psoriasis share significant Th1/Th17 enrichment and upregulation of atherosclerosis-related proteins. Nevertheless, despite the greater body surface area involved in psoriasis, HS presents a greater serum inflammatory burden.