Title | Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/ acne inversa. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Frew JW, Navrazhina K, Marohn M, Lu P-JC, Krueger JG |
Journal | Exp Dermatol |
Volume | 28 |
Issue | 8 |
Pagination | 886-891 |
Date Published | 2019 Aug |
ISSN | 1600-0625 |
Abstract | The precise pathogenic mechanisms in the development, persistence and worsening of hidradenitis suppurativa (HS) remain ill-defined. This chronic inflammatory dermatosis displays a strong Th1 and Th17 inflammatory signature with elevated levels of TNF-α, IL-1β, IL-17 and IFNγ in lesional and perilesional tissue. HS significantly differs to other chronic inflammatory dermatoses due to the development of hypertrophic scarring and dermal tunnels. The development of scarring and tunnels suggests that fibroblastic stromal cells (including myofibroblasts, fibroblasts, pericytes etc) may be involved in the development and progression of disease. Heterogeneous populations of fibroblasts have been identified in other inflammatory disorders and malignancy which contribute to inflammation and present novel therapeutic targets for fibrotic disorders. Findings in HS are consistent with these fibroblast subpopulations and may contribute to tunnel formation, aggressive squamous cell carcinoma and the phenotypic presentation of familial HS variants. We describe the existing knowledge regarding these mechanistic pathways and methods to confirm their involvement in the pathogenesis of HS. |
DOI | 10.1111/exd.13978 |
Alternate Journal | Exp. Dermatol. |
PubMed ID | 31140657 |
PubMed Central ID | PMC6663622 |
Grant List | T32 GM007739 / GM / NIGMS NIH HHS / United States UL1 TR001866 / TR / NCATS NIH HHS / United States T32GM007739 / / National Institute of General Medical Sciences / UL1 TR001866 / / National Center for Advancing Translational Sciences / |
Submitted by bel2021 on December 2, 2019 - 10:17am