The Tri-Institutional MD-PhD Program (Tri-I) is a joint undertaking between Weill Cornell Medicine, The Rockefeller University, and Memorial Sloan Kettering Cancer Center. Trainees complete their MD degree at Weill Cornell Medical College, and PhD training at one of the three participating graduate schools: Weill Cornell Graduate School of Medical Sciences; the David Rockefeller Graduate Program in Bioscience; or the Louis V. Gerstner Jr. Graduate School of Biomedical Sciences. Tri-I guides students through a rigorous course of study that offers flexibility and unfettered access to experienced mentors in leading laboratories. An integrated curriculum reinforces the students’ identities as clinician-scientists; equally well-prepared to work in the laboratory and at the bedside, Tri-I graduates bridge the gap between clinical medicine and laboratory research.