Title | A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Scharschmidt TC, Vasquez KS, Truong H-A, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD |
Journal | Immunity |
Volume | 43 |
Issue | 5 |
Pagination | 1011-21 |
Date Published | 2015 Nov 17 |
ISSN | 1097-4180 |
Keywords | Animals, Animals, Newborn, Antigens, Bacterial, Host-Pathogen Interactions, Immune Tolerance, Inflammation, Mice, Mice, Inbred C57BL, Microbiota, Molecular Sequence Data, Skin, Staphylococcal Infections, Staphylococcus epidermidis, T-Lymphocytes, Regulatory |
Abstract | The skin is a site of constant dialog between the immune system and commensal bacteria. However, the molecular mechanisms that allow us to tolerate the presence of skin commensals without eliciting destructive inflammation are unknown. Using a model system to study the antigen-specific response to S. epidermidis, we demonstrated that skin colonization during a defined period of neonatal life was required for establishing immune tolerance to commensal microbes. This crucial window was characterized by an abrupt influx of highly activated regulatory T (Treg) cells into neonatal skin. Selective inhibition of this Treg cell wave completely abrogated tolerance. Thus, the host-commensal relationship in the skin relied on a unique Treg cell population that mediated tolerance to bacterial antigens during a defined developmental window. This suggests that the cutaneous microbiome composition in neonatal life is crucial in shaping adaptive immune responses to commensals, and disrupting these interactions might have enduring health implications. |
DOI | 10.1016/j.immuni.2015.10.016 |
Alternate Journal | Immunity |
PubMed ID | 26588783 |
PubMed Central ID | PMC4654993 |
Grant List | / ImNIH / Intramural NIH HHS / United States K08 AR068409 / AR / NIAMS NIH HHS / United States DP2-AR068130 / AR / NIAMS NIH HHS / United States DP2 AR068130 / AR / NIAMS NIH HHS / United States K08 AR062064 / AR / NIAMS NIH HHS / United States K08-AR062064 / AR / NIAMS NIH HHS / United States P30 DK043351 / DK / NIDDK NIH HHS / United States R01 AI107020 / AI / NIAID NIH HHS / United States R21-AR066821 / AR / NIAMS NIH HHS / United States 5P30CA082103-15 / CA / NCI NIH HHS / United States U19 AI095261 / AI / NIAID NIH HHS / United States R21 AR066821 / AR / NIAMS NIH HHS / United States P30 CA082103 / CA / NCI NIH HHS / United States P30 DK063720 / DK / NIDDK NIH HHS / United States |
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