Title | Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Gautam S, Kim T, Lester E, Deep D, Spiegel DA |
Journal | ACS Chem Biol |
Volume | 11 |
Issue | 1 |
Pagination | 25-30 |
Date Published | 2016 Jan 15 |
ISSN | 1554-8937 |
Keywords | Antibodies, Cell Wall, Epitopes, Models, Biological, Protein Binding, Staphylococcus aureus, Teichoic Acids |
Abstract | Staphylococcus aureus is a Gram-positive bacterial pathogen that produces a range of infections including cellulitis, pneumonia, and septicemia. The principle mechanism in antistaphylococcal host defense is opsonization with antibodies and complement proteins, followed by phagocytic clearance. Here we use a previously developed technique for installing chemical epitopes in the peptidoglycan cell wall to show that surface glycopolymers known as wall teichoic acids conceal cell wall epitopes, preventing their recognition and opsonization by antibodies. Thus, our results reveal a previously unrecognized immunoevasive role for wall teichoic acids in S. aureus: repulsion of peptidoglycan-targeted antibodies. |
DOI | 10.1021/acschembio.5b00439 |
Alternate Journal | ACS Chem. Biol. |
PubMed ID | 26502318 |
PubMed Central ID | PMC5592732 |
Grant List | T32GM07205 / GM / NIGMS NIH HHS / United States 1DP2OD002913-01 / OD / NIH HHS / United States T32 GM007205 / GM / NIGMS NIH HHS / United States DP2 OD002913 / OD / NIH HHS / United States P30 CA016359 / CA / NCI NIH HHS / United States |
Submitted by api_import on December 20, 2019 - 1:39pm