Viral Teamwork Pushes CRISPR to the Breaking Point.

TitleViral Teamwork Pushes CRISPR to the Breaking Point.
Publication TypeJournal Article
Year of Publication2018
AuthorsNussenzweig PM, Marraffini LA
JournalCell
Volume174
Issue4
Pagination772-774
Date Published2018 08 09
ISSN1097-4172
KeywordsBacteriophages, Clustered Regularly Interspaced Short Palindromic Repeats, Viruses
Abstract

Viruses have evolved inhibitors to counteract the CRISPR immune response, but they are not fully potent and need some time to be expressed after the beginning of infection. In this issue of Cell, Borges et al. and Landsberger et al. show that sequential infection gradually immunosuppresses the host to allow effective CRISPR inhibition.

DOI10.1016/j.cell.2018.07.025
Alternate JournalCell
PubMed ID30096306