Submitted by kej2006 on June 6, 2018 - 4:09pm
Title | Isocitrate dehydrogenase mutations in leukemia. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | McKenney ASophia, Levine RL |
Journal | J Clin Invest |
Volume | 123 |
Issue | 9 |
Pagination | 3672-7 |
Date Published | 2013 Sep |
ISSN | 1558-8238 |
Keywords | Animals, Biomarkers, Tumor, DNA Mutational Analysis, DNA-Binding Proteins, Glutarates, Humans, Isocitrate Dehydrogenase, Leukemia, Molecular Targeted Therapy, Mutation, Missense, Proto-Oncogene Proteins |
Abstract | Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the neomorphic, oncogenic function of IDH mutations affects several epigenetic and gene regulatory pathways. Here we discuss the relevance of IDH mutations to leukemia pathogenesis, therapy, and outcome and how mutations in IDH1 and IDH2 affect the leukemia epigenome, hematopoietic differentiation, and clinical outcome. |
DOI | 10.1172/JCI67266 |
Alternate Journal | J. Clin. Invest. |
PubMed ID | 23999441 |
PubMed Central ID | PMC3754251 |
Grant List | F30 CA183497 / CA / NCI NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States GM07739 / GM / NIGMS NIH HHS / United States |