Submitted by kej2006 on June 6, 2018 - 4:09pm
| Title | Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Lewis BB, Carter RA, Pamer EG |
| Journal | Anaerobe |
| Volume | 41 |
| Pagination | 32-36 |
| Date Published | 2016 Oct |
| ISSN | 1095-8274 |
| Keywords | Animals, Clostridium difficile, Enterocolitis, Pseudomembranous, Humans, Lithocholic Acid, Mice, Inbred C57BL, Microbial Viability, Spores, Bacterial, Virulence |
| Abstract | Clostridium difficile is an anaerobic bacterium that causes diarrheal illnesses. Disease onset is linked with exposure to oral antibiotics and consequent depletion of secondary bile acids. Here we investigate the relationship between in vitro secondary bile acid tolerance and in vivo disease scores of diverse C. difficile strains in mice. |
| DOI | 10.1016/j.anaerobe.2016.05.010 |
| Alternate Journal | Anaerobe |
| PubMed ID | 27241781 |
| PubMed Central ID | PMC5050091 |
| Grant List | P30 CA008748 / CA / NCI NIH HHS / United States R01 AI042135 / AI / NIAID NIH HHS / United States R01 AI095706 / AI / NIAID NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States |