Title | The dimycocerosate ester polyketide virulence factors of mycobacteria. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Onwueme KC, Vos CJ, Zurita J, Ferreras JA, Quadri LEN |
Journal | Prog Lipid Res |
Volume | 44 |
Issue | 5 |
Pagination | 259-302 |
Date Published | 2005 Sep |
ISSN | 0163-7827 |
Keywords | Animals, Esters, Humans, Macrolides, Mycobacterium, Mycobacterium tuberculosis, Polyketide Synthases, Virulence Factors |
Abstract | Recent advances in the study of mycobacterial lipids indicate that the class of outer membrane lipids known as dimycocerosate esters (DIMs) are major virulence factors of clinically relevant mycobacteria including Mycobacterium tuberculosis and Mycobacterium leprae. DIMs are a structurally intriguing class of polyketide synthase-derived wax esters discovered over seventy years ago, yet, little was known until recently about their biosynthesis. Availability of several mycobacterial genomes has accelerated progress toward clarifying steps in the DIM biosynthetic pathway and it is our belief that reviewing the bases of our current knowledge will clarify outstanding issues and help direct future endeavors. |
DOI | 10.1016/j.plipres.2005.07.001 |
Alternate Journal | Prog. Lipid Res. |
PubMed ID | 16115688 |
Grant List | 5 R31 AI054323-02 / AI / NIAID NIH HHS / United States 5 T32 GM070369-02 / GM / NIGMS NIH HHS / United States GM07739 / GM / NIGMS NIH HHS / United States P01 AI056293-01 / AI / NIAID NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:10pm