Title | Self-appraisal in behavioural variant frontotemporal degeneration. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Massimo L, Libon DJ, Chandrasekaran K, Dreyfuss M, McMillan CT, Rascovsky K, Boller A, Grossman M |
Journal | J Neurol Neurosurg Psychiatry |
Volume | 84 |
Issue | 2 |
Pagination | 148-53 |
Date Published | 2013 Feb |
ISSN | 1468-330X |
Keywords | Adult, Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Diagnostic Self Evaluation, Frontotemporal Dementia, Humans, Middle Aged, Nerve Fibers, Unmyelinated, Neuropsychological Tests |
Abstract | OBJECTIVE: Previous work investigating deficits in self-appraisal in behavioural-variant frontotemporal degeneration (bvFTD) has focused on a single domain: social/behavioural processes. We examined whether a domain-specific versus multi-domain model best explains degraded self-appraisal in bvFTD. METHODS: 49 patients with bvFTD and 73 patients with Alzheimer's disease (AD) were administered quantitative assessments of episodic memory, naming and grammatical comprehension. Self-appraisal of cognitive test performance was assessed by asking patients to rate their performance immediately after completing each neuropsychological test. A discrepancy score was created to reflect the difference between patient performance on neuropsychological tests and self-appraisal of their test performance. Self-appraisal for each neuropsychological measure was related to grey matter (GM) density in each group using voxel-based morphometry. RESULTS: bvFTD patients were poor at evaluating their own performance on all cognitive tests, with no significant correlations between self-appraisal and actual performance. By contrast, poor self-appraisal in AD was restricted to episodic memory performance. Poor self-appraisal on each task in bvFTD and AD was related to reduced GM density in several ventral and rostral medial prefrontal regions. Crucially, poor self-appraisal for all domains in bvFTD was related to a specific area of reduced GM density in the subgenual cingulate (BA 25). CONCLUSION: Poor self-appraisal in bvFTD affects multiple domains, and this multi-domain impairment pattern is associated with frontal disease in the subgenual cingulate. |
DOI | 10.1136/jnnp-2012-303153 |
Alternate Journal | J. Neurol. Neurosurg. Psychiatry |
PubMed ID | 22952324 |
PubMed Central ID | PMC3556171 |
Grant List | R01 NS044266 / NS / NINDS NIH HHS / United States P30 AG010124 / AG / NIA NIH HHS / United States R01 AG015116 / AG / NIA NIH HHS / United States AG10124 / AG / NIA NIH HHS / United States NS44266 / NS / NINDS NIH HHS / United States P01 AG017586 / AG / NIA NIH HHS / United States AG15116 / AG / NIA NIH HHS / United States P50 NS053488 / NS / NINDS NIH HHS / United States F31 NR013306 / NR / NINR NIH HHS / United States AG17586 / AG / NIA NIH HHS / United States NS53488 / NS / NINDS NIH HHS / United States F31NR013306 / NR / NINR NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:09pm