Metabolic control of asyMYCtric division.

TitleMetabolic control of asyMYCtric division.
Publication TypeJournal Article
Year of Publication2016
AuthorsDo MH, Li MO
JournalCell Res
Volume26
Issue8
Pagination863-4
Date Published2016 08
ISSN1748-7838
KeywordsCD8-Positive T-Lymphocytes, Cell Division, Lymphocyte Count
Abstract

Asymmetric division in CD8 T cells produces two daughter cells expressing different levels of c-Myc with distinct metabolic profiles. Manipulating this asymmetric partitioning of c-Myc skews T cell responses and potentially allows the development of more effective vaccines and cancer immunotherapies.

DOI10.1038/cr.2016.60
Alternate JournalCell Res.
PubMed ID27197568
PubMed Central IDPMC4973327
Grant ListP30 CA008748 / CA / NCI NIH HHS / United States

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