Title | Essential tremor followed by progressive supranuclear palsy: postmortem reports of 11 patients. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Louis ED, Babij R, Ma K, Cortés E, Vonsattel J-PG |
Journal | J Neuropathol Exp Neurol |
Volume | 72 |
Issue | 1 |
Pagination | 8-17 |
Date Published | 2013 Jan |
ISSN | 1554-6578 |
Keywords | Aged, Aged, 80 and over, Diagnosis, Essential Tremor, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Supranuclear Palsy, Progressive, Surveys and Questionnaires |
Abstract | For many years, clinicians have commented on the development of signs of parkinsonism among their essential tremor (ET) patients, but the links between ET and parkinsonism are not well understood. We report 11 (12.4%) of 89 ET patients who were prospectively collected at the Essential Tremor Centralized Brain Repository during the course of its first 9 years. All patients had long-standing ET (median duration, 38 years); there was a 5- to 49-year latency from the onset of ET to the development of either parkinsonism or dementia.Despite the presence of parkinsonism or dementia during life, none had been diagnosed clinically with progressive supranuclear palsy(PSP). All 11 received the postmortem diagnosis of PSP. The prevalence of PSP in this ET sample (12.4%) is clearly larger than the population prevalence of PSP (0.001%-0.0065%). It is also 2 to 5 times the proportion of normal cases with incidental PSP in 2 previous autopsy series. This case series raises the questions of an association between ET and PSP, whether ET patients are at an increased risk of developing PSP, and what the proportion of ET patients who develop presumed Parkinson disease or Alzheimer disease in life actually have PSP (i.e. ET + PSP). |
DOI | 10.1097/NEN.0b013e31827ae56e |
Alternate Journal | J. Neuropathol. Exp. Neurol. |
PubMed ID | 23242279 |
PubMed Central ID | PMC3530166 |
Grant List | R01 NS39422 / NS / NINDS NIH HHS / United States R01 NS36630 / NS / NINDS NIH HHS / United States T32 NS007153 / NS / NINDS NIH HHS / United States P30 ES09089 / ES / NIEHS NIH HHS / United States R01 NS039422 / NS / NINDS NIH HHS / United States UL1 RR024156 / RR / NCRR NIH HHS / United States T32 NS07153-24 / NS / NINDS NIH HHS / United States R21 NS077094 / NS / NINDS NIH HHS / United States R01 NS073872 / NS / NINDS NIH HHS / United States R56 NS042859 / NS / NINDS NIH HHS / United States R01 NS042859 / NS / NINDS NIH HHS / United States R01 NS036630 / NS / NINDS NIH HHS / United States P30 ES009089 / ES / NIEHS NIH HHS / United States |
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