Title | Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Wang DV, Viereckel T, Zell V, Konradsson-Geuken Å, Broker CJ, Talishinsky A, Yoo JHoon, Galinato MH, Arvidsson E, Kesner AJ, Hnasko TS, Wallén-Mackenzie Å, Ikemoto S |
Journal | Cell Rep |
Volume | 18 |
Issue | 11 |
Pagination | 2584-2591 |
Date Published | 2017 03 14 |
ISSN | 2211-1247 |
Keywords | Animals, Behavior, Animal, Conditioning, Psychological, Dopaminergic Neurons, Glutamic Acid, Mice, Knockout, Neostriatum, Optogenetics, Ventral Tegmental Area, Vesicular Glutamate Transport Protein 2 |
Abstract | Dopamine neurons in the ventral tegmental area (VTA) were previously found to express vesicular glutamate transporter 2 (VGLUT2) and to co-transmit glutamate in the ventral striatum (VStr). This capacity may play an important role in reinforcement learning. Although it is known that activation of the VTA-VStr dopamine system readily reinforces behavior, little is known about the role of glutamate co-transmission in such reinforcement. By combining electrode recording and optogenetics, we found that stimulation of VTA dopamine neurons in vivo evoked fast excitatory responses in many VStr neurons of adult mice. Whereas conditional knockout of the gene encoding VGLUT2 in dopamine neurons largely eliminated fast excitatory responses, it had little effect on the acquisition of conditioned responses reinforced by dopamine neuron activation. Therefore, glutamate co-transmission appears dispensable for acquisition of conditioned responding reinforced by DA neuron activation. |
DOI | 10.1016/j.celrep.2017.02.062 |
Alternate Journal | Cell Rep |
PubMed ID | 28297663 |
PubMed Central ID | PMC5404346 |
Grant List | ZIA DA000575-02 / / Intramural NIH HHS / United States R01 DA036612 / DA / NIDA NIH HHS / United States ZIA DA000575-03 / / Intramural NIH HHS / United States ZIA DA000575-06 / / Intramural NIH HHS / United States ZIA DA000575-04 / / Intramural NIH HHS / United States ZIA DA000575-05 / / Intramural NIH HHS / United States |
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