Title | Clonal production and organization of inhibitory interneurons in the neocortex. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Brown KN, Chen S, Han Z, Lu C-H, Tan X, Zhang X-J, Ding L, Lopez-Cruz A, Saur D, Anderson SA, Huang K, Shi S-H |
Journal | Science |
Volume | 334 |
Issue | 6055 |
Pagination | 480-6 |
Date Published | 2011 Oct 28 |
ISSN | 1095-9203 |
Keywords | Animals, Cell Lineage, Cell Movement, Clone Cells, Gene Knock-In Techniques, Interneurons, Mice, Mitosis, Neocortex, Neural Inhibition, Neural Stem Cells, Neurogenesis, Neuroglia, Preoptic Area, Telencephalon |
Abstract | The neocortex contains excitatory neurons and inhibitory interneurons. Clones of neocortical excitatory neurons originating from the same progenitor cell are spatially organized and contribute to the formation of functional microcircuits. In contrast, relatively little is known about the production and organization of neocortical inhibitory interneurons. We found that neocortical inhibitory interneurons were produced as spatially organized clonal units in the developing ventral telencephalon. Furthermore, clonally related interneurons did not randomly disperse but formed spatially isolated clusters in the neocortex. Individual clonal clusters consisting of interneurons expressing the same or distinct neurochemical markers exhibited clear vertical or horizontal organization. These results suggest that the lineage relationship plays a pivotal role in the organization of inhibitory interneurons in the neocortex. |
DOI | 10.1126/science.1208884 |
Alternate Journal | Science |
PubMed ID | 22034427 |
PubMed Central ID | PMC3304494 |
Grant List | R01 DA024681 / DA / NIDA NIH HHS / United States R21 NS072483-01 / NS / NINDS NIH HHS / United States R01 DA024681-05 / DA / NIDA NIH HHS / United States R21 NS072483 / NS / NINDS NIH HHS / United States R01 DA024681-01A1 / DA / NIDA NIH HHS / United States R21 MH083624-01 / MH / NIMH NIH HHS / United States R21 MH083624-02 / MH / NIMH NIH HHS / United States R21 NS072483-02 / NS / NINDS NIH HHS / United States R01 DA024681-02 / DA / NIDA NIH HHS / United States K02MH070031 / MH / NIMH NIH HHS / United States R01DA024681 / DA / NIDA NIH HHS / United States R21 MH083624 / MH / NIMH NIH HHS / United States R01 DA024681-03 / DA / NIDA NIH HHS / United States K02 MH070031 / MH / NIMH NIH HHS / United States R21MH083624 / MH / NIMH NIH HHS / United States R21NS072483 / NS / NINDS NIH HHS / United States R01 MH066912 / MH / NIMH NIH HHS / United States R01 DA024681-04 / DA / NIDA NIH HHS / United States R01MH066912 / MH / NIMH NIH HHS / United States |
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