Title | Calcium signaling and transcription: elongation, DoGs, and eRNAs. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Vilborg A, Passarelli MC, Steitz JA |
Journal | Receptors Clin Investig |
Volume | 3 |
Issue | 1 |
Date Published | 2016 |
ISSN | 2330-0558 |
Abstract | The calcium ion (Ca) is a key intracellular signaling molecule with far-reaching effects on many cellular processes. One of the most important such Ca regulated processes is transcription. A body of literature describes the effect of Ca signaling on transcription initiation as occurring mainly through activation of gene-specific transcription factors by Ca-induced signaling cascades. However, the reach of Ca extends far beyond the first step of transcription. In fact, Ca can regulate all phases of transcription, with additional effects on transcription-associated events such as alternative splicing. Importantly, Ca signaling mediates reduced transcription termination in response to certain stress conditions. This reduction allows readthrough transcription, generating a highly inducible and diverse class of downstream of gene containing transcripts (DoGs) that we have recently described. |
DOI | 10.14800/rci.1169 |
Alternate Journal | Receptors Clin Investig |
PubMed ID | 29147672 |
PubMed Central ID | PMC5685190 |
Grant List | / / Howard Hughes Medical Institute / United States R01 GM026154 / GM / NIGMS NIH HHS / United States |
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