Submitted by kej2006 on June 6, 2018 - 4:13pm
| Title | Turning up the Heat with Therapeutic Epigenome Editing. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Zezulin A, Musunuru K |
| Journal | Cell Stem Cell |
| Volume | 22 |
| Issue | 1 |
| Pagination | 10-11 |
| Date Published | 2018 Jan 04 |
| ISSN | 1875-9777 |
| Abstract | CRISPR-Cas9 has been touted for therapeutic genome editing, but limitations include inefficient correction of disease-causing mutations and off-target mutagenesis. In the latest issue of Cell, Liao et al. (2017) show that a modified version of CRISPR-Cas9 can target and activate key therapeutic genes in vivo without altering DNA sequence identity. |
| DOI | 10.1016/j.stem.2017.12.013 |
| Alternate Journal | Cell Stem Cell |
| PubMed ID | 29304336 |