Recent Advances in Retinal Stem Cell Therapy.

TitleRecent Advances in Retinal Stem Cell Therapy.
Publication TypeJournal Article
Year of Publication2017
AuthorsBhattacharya S, Gangaraju R, Chaum E
JournalCurr Mol Biol Rep
Volume3
Issue3
Pagination172-182
Date Published2017 Sep
ISSN2198-6428
Abstract

Purpose of review: Progress in stem cell research for blinding diseases over the past decade is now being applied to patients with retinal degenerative diseases and soon perhaps, glaucoma. However, the field still has much to learn about the conversion of stem cells into various retinal cell types, and the potential delivery methods that will be required to optimize the clinical efficacy of stem cells delivered into the eye.

Recent findings: Recent groundbreaking human clinical trials have demonstrated both the opportunities and current limitations of stem cell transplantation for retinal diseases. New progress in developing retinal organoids, coupled with the maturation of bio-printing technology, and non-invasive high-resolution imaging have created new possibilities for repairing and regenerating the diseased retina and rigorously validating its clinical impact .

Summary: While promising progress is being made, meticulous clinical trials with cells derived using good manufacturing practice, novel surgical methods, and improved methods to derive all of the neuronal cell types present in the retina will be indispensable for developing stem cell transplantation as a paradigm shift for the treatment of blinding diseases.

DOI10.1007/s40610-017-0069-3
Alternate JournalCurr Mol Biol Rep
PubMed ID29152454
PubMed Central IDPMC5685516
Grant ListR01 EY023427 / EY / NEI NIH HHS / United States
R01 EY024063 / EY / NEI NIH HHS / United States

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