Submitted by kej2006 on June 6, 2018 - 4:11pm
| Title | Radiotherapy and Immune Checkpoint Blockade for Melanoma: A Promising Combinatorial Strategy in Need of Further Investigation. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Escorcia FE, Postow MA, Barker CA |
| Journal | Cancer J |
| Volume | 23 |
| Issue | 1 |
| Pagination | 32-39 |
| Date Published | 2017 Jan/Feb |
| ISSN | 1540-336X |
| Keywords | Animals, Combined Modality Therapy, Humans, Immunotherapy, Melanoma, Membrane Glycoproteins, Membrane Transport Proteins, Programmed Cell Death 1 Receptor, Randomized Controlled Trials as Topic, Treatment Outcome |
| Abstract | Radiotherapy and immune checkpoint blockade are effective treatments for melanoma. Recent preclinical studies have suggested an interaction of radiotherapy and immune checkpoint blockade. Retrospective clinical studies, as well as a small number of prospective studies, have been undertaken to explore this interaction in patients with melanoma. In this review, we present the results of clinical studies combining radiotherapy and immune checkpoint blockade and conclude that this is a promising strategy worth of further investigation. |
| DOI | 10.1097/PPO.0000000000000236 |
| Alternate Journal | Cancer J |
| PubMed ID | 28114252 |
| PubMed Central ID | PMC5300083 |
| Grant List | P30 CA008748 / CA / NCI NIH HHS / United States |