Title | Noncanonical cell death in the nematode Caenorhabditis elegans. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Kinet MJ, Shaham S |
Journal | Methods Enzymol |
Volume | 545 |
Pagination | 157-80 |
Date Published | 2014 |
ISSN | 1557-7988 |
Keywords | Animals, Apoptosis, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Calcium-Binding Proteins, Caspases, Humans, Necrosis, Proto-Oncogene Proteins c-bcl-2, Repressor Proteins, Signal Transduction |
Abstract | The nematode Caenorhabditis elegans has served as a fruitful setting for cell death research for over three decades. A conserved pathway of four genes, egl-1/BH3-only, ced-9/Bcl-2, ced-4/Apaf-1, and ced-3/caspase, coordinates most developmental cell deaths in C. elegans. However, other cell death forms, programmed and pathological, have also been described in this animal. Some of these share morphological and/or molecular similarities with the canonical apoptotic pathway, while others do not. Indeed, recent studies suggest the existence of an entirely novel mode of programmed developmental cell destruction that may also be conserved beyond nematodes. Here, we review evidence for these noncanonical pathways. We propose that different cell death modalities can function as backup mechanisms for apoptosis, or as tailor-made programs that allow specific dying cells to be efficiently cleared from the animal. |
DOI | 10.1016/B978-0-12-801430-1.00007-X |
Alternate Journal | Meth. Enzymol. |
PubMed ID | 25065890 |
PubMed Central ID | PMC4115798 |
Grant List | T32GM07739 / GM / NIGMS NIH HHS / United States HD078703 / HD / NICHD NIH HHS / United States R01 NS081490 / NS / NINDS NIH HHS / United States T32 GM007739 / GM / NIGMS NIH HHS / United States R01 HD078703 / HD / NICHD NIH HHS / United States NS081490 / NS / NINDS NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:11pm