Submitted by kej2006 on June 6, 2018 - 4:12pm
| Title | No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8 TILs. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Bailis W, Shyer JA, Chiorazzi M, Flavell RA |
| Journal | Cancer Cell |
| Volume | 32 |
| Issue | 3 |
| Pagination | 280-281 |
| Date Published | 2017 09 11 |
| ISSN | 1878-3686 |
| Keywords | Fatty Acids, Glucose, Humans, Lymphocytes, Tumor-Infiltrating, Oxygen, Tumor Microenvironment |
| Abstract | The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8 TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy. |
| DOI | 10.1016/j.ccell.2017.08.013 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 28898693 |
| Grant List | T32 AI007019 / AI / NIAID NIH HHS / United States |