Submitted by kej2006 on June 6, 2018 - 4:13pm
| Title | The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Pate KAMetcalf, Blankson JN |
| Journal | Retrovirology |
| Volume | 14 |
| Issue | 1 |
| Pagination | 52 |
| Date Published | 2017 Nov 21 |
| ISSN | 1742-4690 |
| Abstract | Sensitive assays are needed for the detection of residual viral reservoirs in HIV-1-infected subjects on suppressive combination antiretroviral therapy regimens to determine whether eradication strategies are effective. Mouse viral outgrowth assays have recently been developed and have the potential to be more sensitive than traditional in vitro quantitative viral outgrowth assays. In this article we describe these assays and review several studies that have used them to measure the latent reservoir. |
| DOI | 10.1186/s12977-017-0376-z |
| Alternate Journal | Retrovirology |
| PubMed ID | 29157283 |
| PubMed Central ID | PMC5697021 |
| Grant List | K01 OD018244 / OD / NIH HHS / United States P30 AI094189 / AI / NIAID NIH HHS / United States P30AI094189 / / National Institutes of Health / United States K01OD018244 / / National Institutes of Health / United States R01AI120024 / / National Institute of Allergy and Infectious Diseases / United States |