Submitted by kej2006 on June 6, 2018 - 4:13pm
| Title | Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Kumar RSuresh, Almansour AI, Arumugam N, Althomili DMohammed Q, Altaf M, Basiri A, D K, Manohar TSai, S V |
| Journal | Bioorg Chem |
| Volume | 77 |
| Pagination | 263-268 |
| Date Published | 2018 Apr |
| ISSN | 1090-2120 |
| Abstract | A small library of novel spiropyrrolidine heterocyclic hybrids has been prepared regioselectively in 1-butyl-3-methylimidazoliumbromide ([bmim]Br) with good to excellent yields using a [3+2] cycloaddition reaction. These synthesized compounds were evaluated as potential agents for treating Alzheimer's disease. Compound 4b showed the most potent activity, with an IC of 7.9 ± 0.25 µM against acetylcholinesterase (AChE). The inhibition mechanisms for the most active compounds on AChE and butyrylcholinesterase (BChE) receptors were elucidated using molecular docking simulations. |
| DOI | 10.1016/j.bioorg.2018.01.019 |
| Alternate Journal | Bioorg. Chem. |
| PubMed ID | 29421701 |