Title | Inflammation: A Double-Edged Sword in the Response to Pseudomonas aeruginosa Infection. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Lin CK, Kazmierczak BI |
Journal | J Innate Immun |
Volume | 9 |
Issue | 3 |
Pagination | 250-261 |
Date Published | 2017 |
ISSN | 1662-8128 |
Keywords | Animals, Cytokines, Host-Pathogen Interactions, Humans, Immunity, Innate, Inflammasomes, Inflammation, Opportunistic Infections, Pseudomonas aeruginosa, Pseudomonas Infections |
Abstract | The Gram-negative opportunistic pathogen Pseudomonas aeruginosa exploits failures of barrier defense and innate immunity to cause acute infections at a range of anatomic sites. We review the defense mechanisms that normally protect against P. aeruginosa pulmonary infection, as well as the bacterial products and activities that trigger their activation. Innate immune recognition of P. aeruginosa is critical for pathogen clearance; nonetheless, inflammation is also associated with pathogen persistence and poor host outcomes. We describe P. aeruginosa adaptations that improve this pathogen's fitness in the inflamed airway, and briefly discuss strategies to manipulate inflammation to benefit the host. Such adjunct therapies may become increasingly important in the treatment of acute and chronic infections caused by this multi-drug-resistant pathogen. |
DOI | 10.1159/000455857 |
Alternate Journal | J Innate Immun |
PubMed ID | 28222444 |
PubMed Central ID | PMC5469373 |
Grant List | R01 AI081825 / AI / NIAID NIH HHS / United States T32 GM007205 / GM / NIGMS NIH HHS / United States |
Submitted by kej2006 on June 6, 2018 - 4:11pm