| Title | ICAMs support B cell interactions with T follicular helper cells and promote clonal selection. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Zaretsky I, Atrakchi O, Mazor RD, Stoler-Barak L, Biram A, Feigelson SW, Gitlin AD, Engelhardt B, Shulman Z |
| Journal | J Exp Med |
| Volume | 214 |
| Issue | 11 |
| Pagination | 3435-3448 |
| Date Published | 2017 Nov 06 |
| ISSN | 1540-9538 |
| Keywords | Animals, Antigen Presentation, Antigens, CD, B-Lymphocytes, Cell Adhesion Molecules, Cell Communication, Cell Differentiation, Clone Cells, Flow Cytometry, Germinal Center, Intercellular Adhesion Molecule-1, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Signal Transduction, T-Lymphocytes, Helper-Inducer |
| Abstract | The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and antigen presentation to the Tfh cells. How long-lasting T-B interactions and B cell clonal expansion are regulated by antigen presentation remains unclear. Here, we use in vivo B cell competition models and intravital imaging to examine the adhesive mechanisms governing B cell selection for GC colonization. We find that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate Tfh-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion. Thus, B cell ICAMs promote efficient antibody immune response by enhancement of T cell help to cognate B cells. |
| DOI | 10.1084/jem.20171129 |
| Alternate Journal | J. Exp. Med. |
| PubMed ID | 28939548 |
| PubMed Central ID | PMC5679169 |
Submitted by kej2006 on June 6, 2018 - 4:12pm